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Published:
2020-12-28
The novel coronavirus disease (COVID-19) is spreading globally. Little is known about the risk factors for clinical outcomes of COVID-19 in children. Methodology Eight of 260 children diagnosed with severe COVID-19 pneumonia were included in the study. Thirty-five children with COVID-19 infection matched for age, sex, and date of admission, and classified as non-severe, were randomly selected from hospital admissions. For cases of severe pneumonia due to COVID-19, the most frequent symptoms were dyspnea (87.5%), fever (62.5%) and cough (62.5%). In the laboratory, the white blood cell count was significantly higher in seriously ill children than in non-seriously ill children. Elevated levels of by-products of inflammation such as hsCRP, IL-6, IL-10, and D-dimer in critically ill children compared to non-critically ill children at admission. The level of total bilirubin and uric acid clearly elevated in seriously ill children compared with non-seriously ill children at admission. All critically ill children showed lesions on chest CT scan, more lung segments were involved in critically ill than non-critically ill children, which was the only risk factor associated with severe COVID-19 pneumonia in multivariate analysis.
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